Clearance of amyloid β-peptide from brain: transport or metabolism?
نویسندگان
چکیده
منابع مشابه
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD). The APOE ε4 allele markedly increases AD risk and decreases age of onset, likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. In contrast, the APOE ε2 allele appears to decrease AD risk. Most rare, early-onset forms of familial AD are caused b...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2000
ISSN: 1078-8956,1546-170X
DOI: 10.1038/77397